Harvard researchers at Massachusetts General Hospital (MGH) have found that relatively young men with longstanding HIV infection and minimal cardiac risk factors had significantly more coronary atherosclerotic plaques — some involving serious arterial blockage — than did uninfected men with similar cardiovascular risk. The study, published in this month’s edition of the journal AIDS, is the first to use CT angiography to identify coronary artery plaques in HIV-infected participants.“We were particularly surprised to find that several of the HIV patients – none of whom had symptoms of heart disease – had obstructive coronary artery disease, which was found in none of the controls,” says Janet Lo, MD, a Harvard Medical School instructor in medicine in the MGH Program in Nutritional Metabolism, who led the study. “It appears that both traditional and nontraditional risk factors are contributing to atherosclerotic disease in HIV-infected patients.”Several previous studies have found increased incidence of heart attacks and other cardiovascular events among HIV-infected patients, but it has not been clear whether that risk was attributable to recognized risk factors, such as elevated cholesterol and smoking, or to HIV-related immune system factors. The current study enrolled 110 men – 78 with HIV infection and 32 uninfected controls – without symptoms of cardiovascular disease. Participants ranged in age from 18 to 55, and both groups had low levels of traditional cardiovascular risk factors. The HIV-positive participants had longstanding infection, were generally healthy, and the great majority were receiving antiretroviral therapy.After a detailed interview and physician examination, participants received both a standard cardiac CT scan using a 64-slice multidetector CT scanner and CT angiography. While the cardiac CT scan identifies calcium deposits in coronary arteries, CT angiography can also find non-calcified arterial plaques. The standard scans showed that the HIV-infected participants had levels of coronary calcium that, based on previous studies, would be expected in men who were six years older. The CT angiography revealed coronary atherosclerosis in 59 percent of the HIV-infected patients, compared with only 34 percent of controls. Five of the HIV-positive participants had critical coronary stenosis – 70 percent or greater narrowing of one or more arterial segments – something seen in none of the controls. Those participants were all referred to cardiologists for further evaluation and treatment.“Our findings highlight the need to address reduction of cardiac risk factors early in the course of HIV disease and for caregivers to consider that even asymptomatic patients with longstanding HIV disease and minimal cardiac risk factors may have significant coronary artery disease,” says Lo, who is an instructor in Medicine at Harvard Medical School. “We also found interesting associations between atherosclerosis levels and how long participants had been infected with HIV and with several inflammatory and immune factors. Future studies are needed to clarify the role of these nontraditional risk factors and find the best prevention and treatment strategies for these patients.”Steven Grinspoon, MD, an HMS professor of medicine and director of the MGH Program in Nutritional Metabolism, is senior author of the AIDS report. Additional co-authors are Jeffrey Wei, Program in Nutritional Metabolism; and Sunny Abbara, MD, Leon Shturman, Anand Soni, Jose Rocha-Filho and Khurram Nasir, MGH Radiology. The study was supported by grants from the National Institutes of Health and Bristol Myers Squibb, Inc.
First Published: 30th August, 2019 11:22 IST 1 year ago Cricket rules authority to review controversial World Cup Final overthrow law, details here Press Trust Of India WE RECOMMEND 1 year ago Eoin Morgan’s desire for second World Cup success might be tempered by back concern Written By SUBSCRIBE TO US Last Updated: 30th August, 2019 15:40 IST Shooting World Cup: Abhishek Verma Wins Gold, Chaudhary Bags Bronze Asian Games shooting medallist Abhishek Verma won the gold and Saurabh Chaudhary claimed the bronze as Indian shooters dominated the podium at ISSF World Cup. LIVE TV FOLLOW US 1 year ago Congress reveals: Aikido black-belt Rahul Gandhi also a shooting champ Video Player is loading.Play VideoPlayMuteCurrent Time 0:00Loaded: 0%Duration 0:00Stream Type LIVESeek to live, currently playing liveLIVERemaining Time -0:00 Playback Rate1xChaptersChaptersDescriptionsdescriptions off, selectedSubtitlessubtitles settings, opens subtitles settings dialogsubtitles off, selectedAudio TrackQuality LevelsFullscreenThis is a modal window. This video is restricted from playing on your current domain Error Code: PLAYER_ERR_DOMAIN_RESTRICTED Asian Games shooting medallist Abhishek Verma won the gold while teen sensation Saurabh Chaudhary claimed the bronze as Indian shooters dominated the podium in the men’s 10m air pistol event of the ongoing ISSF World Cup at Rio. Abhishek Verma, a part-time lawyer, shot 244.2 in the eight-man final on Thursday, while the 17-year-old Saurabh Chaudhary’s 221.9 was good enough to get him the bronze after five gold medals this year. The silver medal went to Turkey’s Ismail Keles, who aggregated 243.1 in the season’s fourth ISSF World Cup for rifle and pistol shooters. India are now placed at the top of the medals tally with two gold, one silver and a bronze.Shooting: India’s Elavenil Claims Her Maiden World Cup Gold MedalTeam India shooters ace at RioIndia has already exhausted the maximum Olympic quotas available per country in this event, with both Verma and Chaudhary securing the sports in the previous qualifying events. In the qualification round on Thursday, Chaudhary was fourth with 584 points and Verma entered the finals in fifth position with 582 points, while Gaurav Rana was 44th with 571. The young Elavenil Valarivan opened India’s account with a gold in the women’s 10m air rifle event on Wednesday.READ: Rahul Gandhi A Shooting Champion & Aikido Black Belt; Netizens AlarmedSanjeev Rajput then claimed a silver in the men’s 50m rifle 3 positions final to secure an Olympic quota for India. Abhishek Verma, who won bronze in the Jakarta Asian Games last year, and Chaudhary ended the second day of competitions on a high note for India. For a change, Saurabh Chaudhary had to settle for a bronze this time, his sixth ISSF World Cup medal of the year. He had earlier won a phenomenal five golds. Congress Reveals: Aikido Black-belt Rahul Gandhi Also A Shooting ChampAbhishek Verma and Saurabh Chaudhary scoresThe signs were there early when Verma and Chaudhary, who have now won all the four ISSF World Cup gold medals on offer this year between them, shot scores of 584 and 582 to qualify for the final. Just one and three points separated the duo from the top qualifying score of 585 posted by Ukranian veteran Oleh Omelchuk. Saurabh Chaudhary was comparatively subdued in the final, but it was the Asian Games bronze-medallist Verma, who looked in his elements.In a top-quality final field, featuring the likes of former Olympic and World Champion Pang Wei of China, besides multiple World Cup and World Championship medallists like Omelchuk, Serbian Damir Mikec and Turkish Yusuf Dikec, Verma was placed second till the first series of five shots. He went into the lead from the 12th shot, which is also the first elimination shot of the 24-shot final and never looked back from there, fending of the challenge of Ismail Keles of Turkey with a sublime 10.7 for his final shot to settle the issue. READ: Assam Rifles Team Aces It At World Police And Fire Games, Bags Five Gold Medals In ChinaA 9.6 for his 23rd shot helped the Turk go into the final shot just 0.1 behind, but his hopes were dashed by Verma’s finish. Keles managed only a 9.7 to finish with 243.1, a clear 1.1 behind the Indian. Saurabh Chaudhary, despite his best efforts, won a bronze with a score of 221.9. Earlier in the day, Chinki Yadav came close to making it to the finals, finishing just a point behind the final qualifying mark in the women’s 25m Pistol event. She shot a 294 in the Rapid Fire round, ending up with a solid 584 to claim 10th spot. Switzerland’s Heidi Gerber, who bagged the eighth and final qualifying spot, shot 585 even as Hungary’s Veronika Major claimed her third ISSF World Cup gold of the year in the event. Annu Raj Singh, making a comeback to the Indian team, shot 579 to end in 25th spot while Abhidnya Ashok Patil shot 572 to finish 53rd. Among other Indian competitors on the day, Chain Singh and Parul Kumar, in the men’s 50m Rifle 3 Positions, shot 1161 and 1148 to finish 49th and 57th respectively while Gaurav Rana, in the men’s 10m Air Pistol, shot 571 to claim the 44th spot.READ: Abhishek Verma Secures Olympic Quota Place With Gold In Maiden WC FinalIndian shooters in the non-competition Minimum Qualification Score (MQS) section also had a great day. In the women’s 25m Pistol, Rahi Sarnobat and Manu Bhaker, both of whom have won Tokyo quotas for India, shot solid rounds of 580 and 583 in MQS respectively. Swapnil Kusale and Aishwarya Singh Tomar, shooting in the MQS section of the men’s 50m Rifle 3 Positions, shot rounds of 1166 and 1165 respectively. 1 year ago Shooting: India’s Elavenil claims her maiden World Cup gold medal WATCH US LIVE Session ID: 2020-09-09:b0429d465d01a0d1c6af3fb2 Player Element ID: video_player_5f585c9b50f6f OK Close Modal DialogBeginning of dialog window. 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This modal can be closed by pressing the Escape key or activating the close button.PlayMuteCurrent Time 0:00/Duration 0:00Loaded: 0%Stream Type LIVESeek to live, currently playing liveLIVERemaining Time -0:00 Playback Rate1xFullscreen 1 year ago Imran Khan slams own Pakistan team on ‘mindset’ for World Cup failure COMMENT